Modern medications are a powerful weapon aimed at fighting for the sake of saving human life and health. Anesthesiology, its modern achievements - a vivid example.
about the effects of certain drugs, their effects on the human body.
Due to the major achievements of the basic sciences, at present, the pharmacotherapy of many diseases has become much more effective. Scientific research has been developed in such new fields as the chemistry and pharmacology of peptides , pharmacokinetics, immunopharmacology, pharmacology of receptors and membrane processes, molecular, biochemical, neurochemical pharmacology. Research on age pharmacology has expanded. New data were obtained on the mechanism of action of neurotropic, cardiovascular drugs, drugs that affect hemocoagulation, kidney function, inflammation, immunity, etc.
In the field of pharmacology of the cardiovascular system , new antianginal, antiarrhythmic agents, anticoagulants, fibrinolysis inhibitors have been discovered and introduced into general medical practice. New data were obtained on the study of the mechanisms of action of pharmacological substances on the heart and blood circulation (including the cerebral circulation). Studies on the psychophysiological characterization of the effects of psychotropic drugs , the study of their effect on memory processes are being successfully conducted. The anti-ulcer drug Dimecumaron and the antihistamine fencarol are recommended for medical use. New antibacterial and antiviral drugs have been obtained. Research on the synthesis, pharmacological study and introduction of new effective drugs and physiologically active substances into practice was highly appreciated. For these works awarded the State Prize of the USSR.Go
Special attention is paid to the development of cardiac drugs. Thanks to the drug streptodekaz, for the first time in the world synthesized by Soviet scientists led by academician EI Chazov, it was possible to achieve dissolution of a blood clot in the coronary artery, which opens up new prospects for the treatment of a number of serious heart and vascular diseases.
More than 25 patents have been obtained for medicinal drugs, in particular, for drugs etmozin, nonahlazine, fencarol, etc.
Practical medicine has several thousands of original medicines. If we consider that many of them are produced in the form of combined, then the total number of drugs will be in the tens of thousands. At the same time, their rich arsenal does not always provide a sufficiently effective and safe treatment, since the selection of the most optimal means often does not take into account the large variability of the course of diseases, the individual reaction of the body, as well as the varying degree of suggestibility of patients.
The first stage of drug interaction with the body is absorption, penetration of the drug into the general circulation. Absorption is determined by the method of administration and the nature of the dosage form. So, to ensure the rapid flow of drugs into the blood is most often used parenteral route of administration of its aqueous solutions. On ingestion, absorption occurs more slowly than parenteral absorption. A number of factors affecting absorption from the gastrointestinal tract should be taken into account: physical (degree of dispersion of the drug and its solubility), chemical (the presence or absence of a charged atom in its molecule), physiological (level of peristalsis, blood flow velocity in the wall of the stomach and intestines, character secretion, medication on an empty stomach or after a meal) and pathological (constipation, fever, etc.). Thus, this method of administration does not allow one to accurately predict the rate at which the drug enters the blood, although it is the simplest.