Leukemia (synonym: leukemia, leukemia) is a malignant disease of the blood system, characterized by the growth of immature cells of the hematopoietic tissue that lose their ability to mature. The formed cells displace normal in the blood-forming organs . The proliferation of abnormal cells occurs not only in the bone marrow, but also in other tissues and organs, where normal hematopoiesis does not occur. In addition to normal leukocytes, immature forms enter the peripheral blood. Depending on the type of cells that form the basis of blood formation, and the cellular level at which the loss of ability to mature is found, leukemias are divided into acute and chronic . The latter are divided into myeloid and lymphocytic leukemia . Both chronic and acute leukemia are separate diseases. Special forms of leukemia, which are based on the proliferation of the elements of the reticular stroma proper, are called reticuloses (see). A peculiar clinical and morphological variant of acute leukemia is erythromyelosis (see).
Currently, leukemias are considered as a polyetiological disease of a tumorous nature. In all forms of leukemia, the number of leukocytes can be increased, normal or even reduced. The main diagnostic indicator is the presence of abnormal cells in the bone marrow or in the peripheral blood.Go
Leukemia (from the Greek. Leukos - white; synonym: leukemia, leukemia) - systemic diseases characterized by progressive hyperplastic and metaplastic growth of the initial cells of the reticular stroma and their initial transformations into various blood parenchyma cells. This process in leukemia is aggressive in nature with a generalized lesion of systems and organs; it occurs due to the malignancy of hematopoietic cells and the loss of their ability to differentiate (anaplasia). Depending on what cellular level anaplasia is found in, it is customary to subdivide leukemias into reticulosis, hemocytoblastosis, myeloid leukemia, lymphatic leukemia, erythromyelose, megakaryocytic leukemia. In patients with leukemia, the malignancy of hematopoietic cells finds its expression in a wide variety of structural and cytochemical changes both in the nucleus and in the cytoplasm, making them less similar or completely different from physiologically preserved hemopoiesis cells.
- Etiology and pathogenesis
- Pathological anatomy
- The clinical picture, diagnosis and treatment
- Leukemia after radiation exposure
- Skin manifestations of leukemia
- Leukemia in children