Ligna disease (synonyms: cystinosis, cystine deposition disease) is manifested from the second half of the year lack of appetite, constipation, polydipsia and polyuria. Pathognomonic amino aciduria. In the blood: hypophosphatemia, normoazotemia, lowering blood pH, hypokalemia. Often D-resistant rickets, osteoporosis, growth arrest. Significant detection of cystine crystals and tyrosine needles in the bone marrow and the deposition of cystine in the cornea of the eyes.