Liposarcoma (Greek. Lipos - fat + sarcoma; synonym: fetal cell lipoma, infiltrating lipoma, lipomixoma, myxomyoma) - a malignant tumor that develops from adipose tissue. It occurs in individuals of both sexes, regardless of age, in any part of the body that contains adipose tissue, but is most often observed in the lower extremities and in the retroperitoneal area.
Liposarcoma is usually a tumor of considerable size, usually well defined, but not completely surrounded by a capsule; yellow, granular, with foci of necrosis and hemorrhages. With intermuscular growth, the tumor is dense, pale, a viscous transparent liquid is released on the incision.
Microscopically, a tumor consists of clusters of large spindle-shaped cells, sometimes in the form of a mulberry, and containing numerous granules of neutral fat in the protoplasm. Marked polymorphism of cells, numerous figures of mitoses are noted. The intermuscular type of liposarcoma resembles a lipoma (see), containing a large number of sarcomatous cells, some of them have a spider-like appearance, in some areas the tumor contains a large amount of mucus.
Liposarcoma is usually detected by chance when it reaches a large size. On examination and palpation, it is a soft-elastic, delimited, lobed tumor with a granular surface.
In some cases, cytological examination of tumor punctate can help establish the diagnosis. Liposarcoma gives early common metastases. Some species are more likely to relapse, metastasize slowly.
The main method of treatment is wide surgical removal of the tumor within healthy tissue. Postoperative radiotherapy may be useful, especially for recurrent tumors.