Go Locus minoris resistentiae (place of least resistance)

Locus minoris resistentiae

Locus minoris resistentiae (the place of least resistance) is an organ, tissue or system of the body, primarily exposed to damage in various diseases. Locus minoris resistentiae can be caused by age-related features of an organism (for example, diseases of the gastrointestinal tract in children with many infections), previous injuries and diseases of a particular organ or system, neuroendocrine disorders, etc. Locus minoris resistentiae often determines the localization pathological process, since when exposed to the body, an organ that is less resistant to the influence of the pathogenic agent may undergo damage to the body due to the above factors.

For successful prevention, diagnosis and treatment it is very important to establish locus minoris resistentiae.

Locus minoris resistentiae is the place of least resistance, i.e. an organ, tissue or system of the body, primarily exposed to damage in various diseases.

Locus minoris resistentiae has a significant impact on the course of various diseases, including infectious diseases, causing localization and features of the pathological process.


The primary lesion of the vessels of an organ in arteriosclerosis, the localization of the infectious process (tuberculosis, syphilis, brucellosis, etc.) in certain organs, the localization of skin diseases, etc., is largely determined by the presence of L. mr in the body. Locus minoris resistentiae there may be anatomical and physiological features of the development of organs, disorders of the neuroregulatory and metabolic processes of the body, injuries, occupational poisonings, prolonged exposure to excessively low or high temperature, disruption of secretions hormones, etc. A common cause of L. mr in the body is a previous illness, accompanied by morphological and functional changes that can remain hidden for a long time due to the presence of compensatory processes.

Locus minoris resistentiae is not always limited to any particular organ, but can capture tissue systems, regardless of their organ affiliation. L. mr of this kind is observed, for example, in collagenoses. In the mechanisms of Locus minoris resistentiae, a significant role is played by trace reactions to transferred irritations, as well as pathological reflexes (A. D. Speransky), on the basis of which a new stimulation of the body can serve as a pretext for renewing the old, seemingly eliminated, pathological process. For example, a healed ulcer may recur if you have the flu. The timely detection of Locus minoris resistentiae is an important condition for the successful treatment of many diseases, in connection with which the doctor’s familiarity with the patient’s history is of particular importance.