Digitalis is a herbaceous perennial plant. The following types are used in medical practice: digitalis purpurea (Digitalis purpurea), digitalis woolly (Digitalis lanata), digitalis rusty (Digitalis ferruginea) and digitalis ciliated (Digitalis ciliata). Digitalis has a specific cardiotonic effect due to the presence of cardiac glycosides (see). With the introduction of the inside action of digitalis develops after a certain latent period. Digitalis glycosides are slowly released from the body, and therefore they have a cumulative effect, which is most pronounced in digitoxin and least - in digoxin. Used digitalis in heart failure with symptoms of stagnation in the small and large circles of blood circulation, with valve disease, tachyarrhythmic forms of atrial fibrillation , myocardial dystrophy.
The therapeutic efficacy of digitalis is expressed in an increase in minute blood volume, a decrease in venous pressure, a decrease in circulating blood, acceleration of blood flow, a decrease in heart size, normalization of blood pressure, an increase in lung vital capacity, an increase in diuresis, and disappearance of edema.Go
During treatment, it is necessary to carefully monitor the cardiovascular system and the general condition of patients. It should also take into account the possibility of individual hypersensitivity to digitalis drugs. In the event of toxic effects (cardiac arrhythmias, gastrointestinal and nervous disorders) make a break in treatment. In severe cases, use of potassium salts, procainamide, camphor, atropine, ephedrine , magnesium sulfate and other means.
Digitalis red (purple) (Digitalis purpurea)
Treatment with foxglove preparations is usually carried out by prescribing maximum doses in the first 2-5 days (to achieve the full therapeutic effect), and then maintenance doses, the level of which is determined by the degree of glycoside release. With the introduction of veins into the vein digitalis pre-diluted in 10-20 ml of 20-40% glucose solution.
Digitalis preparations are contraindicated in patients with severe bradycardia, complete atrioventricular block, and an increase in angina attacks.Go
Drugs of foxglove purpurea . The powder of foxglove leaves (Purvis foliorum D.) is used in 0.05–0.1 g 2-3 times a day inside and in candles. The highest single dose of 0.1 g, daily - 0.5 g. Digitoxin (Digitoxinum; synonym: Carditosin, etc.; list A ) - cardiac glycoside. Applied internally at 0.1–0.2 mg 2–3 times a day for 3-5 days, then 0.05–0.1 mg 1–2 times a day. Product form: 0.1 mg tablets. G and toxin (Gitoxinum; list A) is a cardiac glycoside, somewhat weaker than digitoxin. Assign inside of 0.3-0.4 mg 2-3 times a day, followed by lowering the dose to 0.1-0.2 mg. Product form: 0.2 mg tablets. Gitalen (Gitalenum; list B ) - Novogalenov drug. Apply internally 10-15 drops 2-3 times a day; the highest single dose of 0.75 ml, daily - 1.5 ml. Digipurenum (Digipurenum) - a solution (in 70% alcohol) of the amount of purified digitalis glycosides. Assign 10-15 drops 2-3 times a day or in the form of mikroklizm. Product form: 15 ml flasks. Cordigit (Cordigitum; List B): contains digitoxin, gitoksin and other digitalis glycosides. It is convenient for long-term use, as it has a smaller, cumulative effect than digitoxin. Assign the inside of 1 / 2-1 tablet 2-4 times a day. Forms of release: tablets of 0.8 mg and suppositories of 0.8 and 1.2 mg.
Drugs of foxglove woolly differ from drugs of foxglove purpurea more rapid action and less cumulative effect. Celanid (Celanidum; synonym Isolanid; list A) is a cardiac glycoside. Apply inward on 0,25 - 0,5 mg 2 - 3 times a day and in a vein on 1 - 2 ml of 0,02% of solution. Method of production: tablets of 0.25 mg and 1 ml ampoules of 0.02% solution. Digoxin (Digoxinum; synonym Cordioxyl; list A) is a cardiac glycoside. Assign the inside first at 1 mg, and then at 0.25-0.125 mg per day; 1-2 ml of 0, 025% solution is injected into the vein. Forms of release: tablets on 0,25 mg, bottles on 15 ml and ampoules on 2 ml of 0,025% solution. Abicin (Abicinum) - the sum of genuin glycosides. Application, dosage and release form are the same as for celanide. Lanthoside (Lantosidum; list B) is a novalogen preparation. Assign inside of 10-20 drops 2-3 times a day. The highest single dose of 25 drops, daily - 75 drops. Dilaniside (Dilanisidum; list B) - Novogalenov drug. Enter into a vein in 0.5-1 ml. Form release: 1 ml ampoules. The highest single dose of 1 ml, daily - 2 ml.
Preparations of foxglove rusty . Digalen-neo (Digalen-neo; list B) - Novogalenov drug. Assign inside of 5-15 drops 2-3 times a day. The highest single dose of 20 drops, daily - 60 drops; under the skin, respectively 1 and 3 ml. Forms of release: bottles on 15 m and ampoules on 1 ml. Satiturani (Satiturani): contains the amount of digitalis glycosides. Apply inside 1-2 tablets 2-3 times a day. Release form: tablets.
Preparations of foxglove ciliary . Digicil (Digicilum) - Novogalenov drug. Assign 0.5-1 tablet 2-3 times a day. Release form: tablets. Digicilen (Digicilenum; list B.) - Novogalenov drug. Enter under the skin or into the muscles in 0.5 - 1 ml 1-2 times a day. Form release: 1 ml ampoules.