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Protein therapy

Protein therapy is treatment with protein substances parenterally injected into the body.

Blood is used for protein therapy (see. Hemotherapy), including the patient's own blood (see Autohemotherapy) and other protein substances (for example, milk). A variety of protein therapy.
is tissue therapy proposed by V.P. Filatov.

Parenteral administration of a protein preparation is accompanied by a general reaction of the body — a rise in temperature, a temporary deterioration in well-being and a local reaction, expressed in the lesion with increased hyperemia, and in the area of ​​administration of a protein preparation, the appearance of inflammation.

As a result of protein therapy, the body's reactivity changes, its defenses increase, and the activity of the reticuloendothelial system increases.

Indications - chronic infectious and infectious-allergic diseases (for example, joints), peptic ulcer , trophic ulcer , etc.

Contraindications - pronounced atherosclerosis, cardiovascular or renal failure , as well as increased sensitivity to protein drugs.

Complications: anaphylactic shock (see Anaphylaxis ) and serum sickness.

Treatment of complications - see. Serum sickness .

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Protein therapy (protein + Greek. Therapeia - treatment) - treatment with protein substances introduced into the body parenterally. Protein therapy is non-specific, or irritation therapy.

Protein substances are used: own blood — autohemotherapy (see), donor blood — isohemotherapy (see. Hemotherapy), foreign blood — heterohemotherapy, milk — lactotherapy, own blood serum — auto-serum or alien serum (horse, bovine, lamb, etc.) - serotherapy (see), various vaccines - vaccine therapy (see), antitoxic serums (diphtheria, tetanus, etc.), own pus - autobiotherapy.

Lactic therapy is carried out skimmed cow's milk, sterilized by boiling in a fire or water bath for 10 minutes. In the milk prepared in this way, it is not always possible to completely destroy the entire bacterial flora. Milk is injected intramuscularly, starting at 0.5 ml and gradually increasing the dose to 10 ml at 3-4-day intervals; only 10 injections. Often used 5% casein solution of milk. A number of standardized preparations from milk have been proposed: yatrenkazein, caseosan, lactalbumin, etc. Egg protein, deuteroalbumosis, peptone, nucleic acid in the form of soda salt (nucleotherapy), crystalline plant protein (protin, novprotin), etc. were also used. V.P. Filatov tissue therapy is one of the varieties of protein therapy, but of a more complex genesis.

The protein administered parenterally, depending on the reactivity of the organism, the dose and nature of the protein preparation, causes a more or less pronounced local and general reaction.

The general reaction can last several days and is expressed in an increase in temperature. The state of health worsens: an indisposition, general weakness, sometimes pains in joints and muscles appear. These complaints as the temperature drops pass. The basal metabolism, the number of leukocytes, globulin fractions of the protein, the enzymatic activity of the blood and the formation of antibodies are increased. The activity of the reticuloendothelial system, its phagocytic ability and the activity of the adrenal glands increase.

Local reaction may be in the outbreak of the pathological process (focal reaction) or in the area of ​​drug administration. Focal reaction (rush of blood to the affected organ, increased inflammation) contributes to the elimination of the local pathological process. However, an overly strong reaction may contribute to the spread of infection (for example, generalization of the tuberculosis process, etc.). It is very useful to combine specific vaccine therapy and drug therapy with protein therapy. In addition to focal, there is a local inflammatory reaction in the area of ​​the introduction of the protein preparation. Protein therapy changes the reactivity and increases the protective activity of the body, its resistance. The drug, dose and route of administration must be selected carefully, taking into account the nature of the disease and the reactivity of the organism.

Complications: anaphylaxis, serum sickness.

The indications for protein therapy are most often chronic infectious-allergic diseases of the joints, sluggish purulent skin diseases, hydradenitis, trophic ulcers and other chronic infections (chronic gonorrhea, chronic dysentery, etc.). In cases of chronic infection, protein therapy should be combined with antibacterial agents (antibiotics, etc.).

Contraindications to the use of protein therapy: pronounced atherosclerosis, circulatory failure, kidney and liver disease, exhaustion.