Testosterone propionate (Testosteronum propionicum) - Δ4-androsterone-3-one-17- (β) -ol-17-propionate. Ester of propionic acid and testosterone. Synthetic drug male sex hormone. It has the same biological and healing properties as the natural hormone. White or yellowish crystalline powder. Soluble in vegetable oils, alcohol, ether, chloroform, insoluble in water. Melting point 118-123 °. More active (2-3 times) than methyltestosterone. Along with androgenic action has a pronounced anabolic effect, promoting the assimilation of protein by tissues.
Testosterone helps to increase the sex glands and organs, strengthens their activity, stimulates spermatogenesis in small doses, in large doses, it depresses it. In young people, it accelerates growth, increases mental activity and physical strength.
Testosterone is ineffective with impotence, depending on nerve moments, and with infertility, depending on the absence of spermatogenesis or necrospermia.
Testosterone affects the development of secondary sexual characteristics in men. In the mechanism of action of testosterone, as well as other androgens, its inhibitory effect on hormones of the anterior lobe of the pituitary gland matters.Go
In women, testosterone and other androgens suppress the onset of the menstrual cycle and lactation in cases where estrogens cannot be administered (tumors of the uterus, ovaries, and mammary glands). In this regard, they are used to suppress lactation and stop the functional uterine bleeding, with menopausal disorders.
Indications . Postcastration syndrome. Atrophy of the male sex glands. Cryptorchidism. The enlargement of the prostate gland in the elderly. Male menopause. Bed-wetting. Metrorrhagia.
When eunuchoidism, congenital hypoplasia of the gonads, post-extraction syndrome, men are prescribed 0,025 daily or 0.05 every other day or two days later on the third. The duration of treatment depends on the effectiveness of treatment and the severity of the underdevelopment of the sexual apparatus. When the condition improves and the appearance of secondary sexual characteristics, the dose of the drug is reduced to 0.025-0.05 per week.
With a premature decrease in the hormonal function of the testes, early male menopause, 0.025 of the drug is prescribed 3-4 times a week, followed by a dose reduction to 0.05 per week.
In hypertrophy of the prostate gland in the initial stage, 0.01 testosterone propionate is prescribed every other day for 1-2 months.
Women with functional uterine bleeding is prescribed 0.01-0.025 of the drug every other day for 20-30 days before the cessation of bleeding. With the recurrence of bleeding, repeat the treatment.
In case of vascular and nervous disorders of climacteric origin and the presence of contraindications for treatment with estrogens (tumors of the ovaries, uterus, mammary glands), testosterone propionate is administered 0.01 every other day or 0.025 twice a week for several weeks. It is better to prescribe methyltestosterone in such cases.
In uterine myomas that do not require urgent surgery, and prolonged heavy functional uterine bleeding in the period close to menopause, the drug is injected 0.025 3-4 times a week for a month.
In inoperable forms of breast cancer and after surgery, in the presence of early metastases, roentgenotherapy is combined with the administration of testosterone-propionate 0.05 daily for 2–3 months.
Testosterone propionate is used for such vascular disorders as angina pectoris, obliterating endarteritis, and hypertension of I — II stages. It contributes to the expansion of blood vessels, improve blood supply to the relevant organs.Go
With stenocardia and essential hypertension of stages I and II, testosterone propionate is administered intramuscularly at 0.01-0.025 twice a week. The course of treatment consists of 15-25 injections. Along with the introduction of the drug prescribed sedative and antihypertensive drugs.
The use of testosterone-propionate in angina pectoris leads to a decrease in the strength and frequency of pain attacks, and in some cases, to the disappearance of them.
However, sex hormones can not replace the drugs of digitalis and strophant in the expressed syndrome of cardiovascular insufficiency, they complement the action of these drugs.
The effectiveness of hormonal therapy in hypertension is determined by the stage of the disease and the degree of development of concomitant atherosclerotic vascular changes. In hypertensive disease of the first stage, treatment with testosterone propionate promotes the disappearance of complaints, the appearance of a sense of vivacity, normalization of blood pressure.
In stage II of the disease, hormonal therapy reduces headaches, pain in the heart area, dizziness, but does not reduce blood pressure.
A combination of male and female sex hormone is used to treat obliterating endarteritis. Folliculin (synestrol, octestrol) is administered intramuscularly at a rate of 10,000 units 2 times a week in combination with testosterone propionate at 0.01 once a week. The course of treatment consists of 24 injections of folliculin and 12 injections of testosterone propionate.
Contraindications . Pronounced atherosclerosis. Myocardial infarction in the past. Heart failure. Benign prostatic hypertrophy. Sexual impotence, not associated with hypofunction of the sex glands.
Absolute contraindication . Prostate cancer.
Higher doses: single and daily in the muscles (for adults) 0.05.
Forms of release . 1; 2.5 and 5% solution in oil in 1 ml ampoules (0.01; 0.025 and 0.05 in 1 ml respectively).
It is preserved with caution in a dry, dark place at room temperature.
Refers to list B.
Rp. Sol. Testosteroni propionici oleosae 1% 1.0.
D. td N. 6 in ampulis.
S. In the muscles of 1 ml two days later on the third.