Thyreoidin (Thyreoidinum, a synonym: Thyranon, Thyroid, Thyrotan) is a hormonal drug of the thyroid gland . Manufactured from dried glands slaughtered cattle.
Powder of yellow-gray color with a weak odor, characteristic for dried animal tissues. Thyreoidin is insoluble in water, alcohol and other solvents . Has biological activity of the thyroid hormone. The action of thyroidin is associated with the presence in it of two hormones: thyroxine and triiodothyronine. Both hormones increase energy processes in the body, increase the need for tissues in oxygen, increase glucose uptake and its utilization, affect the functional state of the nervous and cardiovascular system , liver, kidneys.
Thyroidine is prescribed (in relatively small doses) with insufficient thyroid function and (in higher doses) with excessive thyrotropic function of the pituitary gland.
The main indications for its use are: hypothyroidism, myxedema, cretinism, cerebro-pituitary diseases, with hypothyroidism, thyroid cancer, euthyroid goiter .
Higher doses for adults inside: single dose - 0.3 g, daily - 1 g; for children under 6 months of age: single - 0.01 g, daily - 0.03 g; from 6 months. up to 1 year: single - 0.02 g, daily - 0.06 g; at the age of 2 years: single - 0.03 g, daily - 0.09 g; 3-4 years: single - 0.05 g, daily - 0.15 g; 5-6 years: single - 0,075 g, daily - 0,25 g; 7-9 years: single - 0.1 g, daily - 0.3 g; 10-14 years: single - 0.15 g, daily - 0.45 g.The
Form release: powder and tablets of 0.05, 0.1 and 0.2 g. Storage: List B.
Thyreoidinum. Dried and powdered thyroid gland. Contains hormones of the thyroid gland. Fine amorphous brownish-yellow powder with a weak odor, insoluble in water. Contains 0.17-0.23% of iodine.
Indications . Myxedema. Hypothyroidism. Cretinism. Endemic goiter. Obesity. Edema. Nephroses. Pituitary dwarf growth. Tetany. Constipation. Eczema. Ichthyosis. Scleroderma.
Contraindications . Thyrotoxicosis. Tuberculosis. Increased nervous and mental excitability. Depletion on the basis of tuberculosis, infectious diseases. Diabetes. Hypertonic disease.
Method of application . When the forms of myxedema are expressed, thyroidin is prescribed 0.2 to 2-3 times a day with a gradual decrease in dose as the symptoms of myxedema disappear to 0.1 to 1-2 times a day, with interruptions in reception per day every two days.
Since the use of thyroidin in thyroid hypothyroidism is a substitution therapy, the effect of which lasts only during the administration of the drug, it is necessary to take the drug systematically throughout life.
In cases of moderate hypothyroidism, 0.1 thyroidin is prescribed daily and every other day.
Children of the first years of life are given 0.05-0.1 thyroid per day, schoolchildren for 0.1-0.2 per day.
The attending physician should select the optimal dose of the drug in each case.
When endemic goiter is recommended, thyroidin is 0,05-0,1 per day or every other day, which does not cause signs of thyrotoxicosis and can be used for a long time (OV Nikolaev, 1961).
In case of obesity, thyroidin is prescribed in doses up to 0.4-0.6 per day in combination with diet, unloading days, and physical exercises.
The drug is also used for edema, regardless of their origin (renal, cardiac, etc.). In the mechanism of this action, direct influence on the pituitary mechanism of diuresis is important. Cardiac patients require caution when taking medication.
With nephrosis, developmental lag and some forms of hypotrophy in children, the drug also benefits.
In tetany, the combination of thyroidin and parathyroidin has a beneficial effect, increasing the release of phosphorus and calcium in urine and feces and increasing the content of these elements in the blood.
With constipation, which is not amenable to conventional therapy, thyroidin also works well, probably through the autonomic nervous system. Treatment is short-lived - for several days.
Higher doses for adults: single 0.3, daily 1.0. Higher doses for children under 6 months of age: single 0.01, daily 0.03; from 0,5 to 1 year: single 0,02, daily 0,06; from 1 to 2 years: single 0.03, daily 0.09; from 3 to 4 years: single 0.05, daily 0, 15; 5- 6 years: single 0,075, daily 0,25; 7-9 years: single 0,1, daily 0,3,! 0-14 years: single 0,15, daily 0,45.
Treatment with thyroidin requires monitoring the heart rate. With persistent tachycardia, the drug is stopped.
Form of issue . Powder and tablets of 0.1 and 0.2.
Keep with care in a cool dry place protected from light. Shelf life is three years.
Refers to list B.
Rp. Thyreoidini, 0.1.
D. td N. 20 in tabulettis.
S. 1 tablet 2-3 times a day.
Rp. Thyreoidini 0.05.
M. f. pulvis. D. td N. 30.
S. 1 powder twice a day for a child of 10 years.