Tissue fluid is a fluid that circulates in the extracellular and peri-cellular spaces of all tissues and organs. It is a medium intermediate between the blood and body tissues. From the tissue fluid, the tissue cells absorb the substances necessary for their vital activity and bring there their metabolic products. Having organ specificity, the tissue fluid in its composition is close to the blood plasma, differing only in a lower protein content. The amount and composition of the tissue fluid depends on the permeability of the walls of arterioles, capillaries and venules, lymph outflow and characteristics of the metabolism of organ cells.
See also Fabric .