Triamcinolone (Triamcinolonum; List B ) is a hormonal drug. By the nature of the action is close to cortisone (see), dexamethasone (see), and other glucocorticosteroid drugs, but in some cases it is better tolerated by patients. Indications for use and contraindications are the same as for cortisone. Assign triamcinolone inside; daily dose of 0.008-0.02 g in 3-4 doses; after the onset of the therapeutic effect, the dose is reduced to 0.001 g per day.
Triamcinolone release form: tablets of 0.004 g.
Triamcinolone (Triamcynolon) - 16-a-hydroxy-9-a-fluoro-prednisolone. Derived forhydrocortisone. It has a pronounced effect on carbohydrate metabolism, exceeding 2-3 times the effect of prednisone. At the same time, sodium ions are retained much less than dexamethasone.
In the experiment, the glycocorticoid effect of triamcinolone is 14 times stronger than cortisone; anti-inflammatory activity is 4 times higher.
Indications and contraindications, see Cortisone.Go
In patients with rheumatoid arthritis, triamcinolone was effective even in cases when prednisone was not active; its maintenance dose is 1 / 3-1 / 5 lower than with prednisone treatment, and almost 10 times less than the dose of cortisone.
In bronchial asthma and other allergic diseases, half the doses of triamcinolone are sufficient compared with prednisone, and the side effects are much less.
Due to the fact that triamcinolone retains sodium much weaker than other glycocorticoids, it is used in doses of 0.012-0.02 per day for congestive heart failure in cases of failure of cardiac and diuretic therapy and for valvular heart disease without signs of rheumatic process.
With paroxysmal muscle paralysis of the hypokalemic type, 0.002–0.004 triamcinolone per day is prescribed. This gives grounds to avoid paralysis (O. Kuchel, 1963).
Triamcinolone does not affect arterial blood pressure and even removes the effects of hypertension, which developed as a result of the use of other corticoids.
Side effects Decreased appetite. Nausea. The secretion and acidity of the gastric juice does not increase. In contrast to other corticosteroids, triamcinolone causes a decrease in weight (even in healthy people), which causes it to refuse the drug after prolonged use.
Approximately 10% of patients may develop symmetric atrophy of the muscles, severe muscle weakness, possibly associated with the action of the fluorine atom contained in the preparation.
With prolonged use, osteoporosis, bone fractures, and pronounced facial flushing, which are not found in the treatment of other corticosteroids, can develop. Mental depression, drowsiness, subcutaneous hemorrhage, and a decrease in carbohydrate tolerance may occur.
Triamcinolone acetonide is very promising, which was used 10 times as strong as triamcinolone in an experiment on animals.
Form release . Tablets of 0.001; 0,002 and 0,004 drugs.