Darya disease (a synonym for follicular dyskeratosis) is a chronic, relatively rare skin disease characterized by the appearance of cone-shaped nodules ranging in size from 2 to 5 mm in diameter of yellow-brown or brown color. Nodules are connected most often with hair follicles, their surface is covered with dense yellowish-dirty color crusts, with violent rejection which markedly impress. Elements are located focally or symmetrically, are prone to the formation of plaques, are covered with horny masses. Primary localization: the scalp, neck, face (the area of nasolabial folds), interscapular space, axillary cavities, folds of the mammary glands, gluteal and pahoe-femoral folds, rear of the hands and feet.
Eruptions sometimes have the appearance of warts or omozolelicities with an impression in the center. On adjoining sites of a skin elements quite often form plaques with fetid moknutie.
Fig. 1. Nodular rashes on the back.
Fig. 2. Rashes, reminiscent of juvenile warts.
A rare variety of Darya's disease are the bubble and hypertrophic forms. In Darya disease, the following symptoms can be observed: premature graying , hyperpigmentation of the hair in the elderly, dystrophy of the teeth, changes in nail plates that become opaque and are streaked with longitudinal whitish grooves; dementia ; endocrine disorders, etc.
The disease is usually older than 10-15 years, but sometimes children suffer in the first years of life.
The cause of Darya's illness is not clear. In many cases, it is family, hereditary. In the pathogenesis of Darya's disease, dysfunctions of the sexual glands, vitamin A deficiencies are assigned a certain role.
Some improvement can be obtained by applying Vitamin A up to 150,000 IU per day, corresponding hormones for endocrine pathology, diathermocoagulation of individual formations, rubbing 2-5% of sulfur-salicylic ointment, sulphide baths (preferably in a spa).