Depigmentation is a discoloration of the skin as a result of impaired pigmentation. Depigmentation can be congenital and acquired, universal (albinism) and partial (vitiligo). Depigmentation can be a manifestation of syphilis (syphilitic leukoderma) and other diseases or develop a second time, for example, at the site of resorbed plaques of psoriasis , etc.
Depigmentation - skin loss of its normal color in one or more areas. These sites are sharply limited. Sensitive and secretory functions of the skin in the depigmented areas do not suffer. Histologically, the skin in the places of depigmentation is not changed, only in the cells of the basal layer of the epidermis and the upper part of the dermis the number of melanophores may be insignificant.
Depigmentation can occur with thyrotoxicosis, diabetes mellitus and chronic adrenal insufficiency.
Treatment of the underlying disease most often does not cause the disappearance of depigmentation.