Deoxycorticosterone trimethyl acetate (Desoxycorticosteronum trimethylaceticum).
Pharmachologic effect. The drug retains sodium and water in the body and enhances the excretion of potassium, increases blood pressure, has a beneficial effect on muscle tone.
Indications. Addison's Disease. Relative insufficiency of the adrenal cortex. Shyhen syndrome Simmonds Disease. Diencephalic-pituitary insufficiency. Hypotonic syndrome. Asthenic state with hypotension after infectious diseases or surgeries.
Contraindications. Hypertension. Diseases of the kidney with insufficiency of function.
Mode of application. It is administered intramuscularly in a dose of 1 ml of a 2.5% aqueous suspension 1 time in 2 weeks.
Blood pressure control and blood tests for potassium and chlorides are required. With an overdose, there are headaches, tissue swelling, increased blood pressure, arthritis. In such cases, reduce the dose and limit the use of salt.
When treating the drug, the patient should consume food rich in potassium. With a decrease in the potassium content in the blood, chloride or potassium acetate is prescribed in 0.5-1.0 g 2-3 times a day.
Refers to list B.
Available in ampoules of 1 ml - 0.025 g of the substance in the form of an aqueous suspension of small crystals.