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Alloxan Diabetes

Alloxan diabetes is diabetes mellitus caused by the introduction of alloxan into a vein or under the skin. When this occurs, the degeneration or necrosis of β-cells of the islets of Langerhans. After 1-2 hours after administration of alloxan, animals develop hyperglycemia due to the breakdown of glycogen in the liver. Then in 24-36 hours hyperglycemia and glycosuria occurs. In the first 10—15 days, changes in the liver, kidneys, and blood-forming organs can also be observed, so insulin deficiency is studied after this period. In alloxan diabetes, the excretory function of the pancreas does not change. Acidosis develops rarely, and experimental animals can live long without the use of insulin. Alloxan diabetes can occur in patients who received alloxan for malignant non-idioblastoma.