Dimestrol (Dimoestrolum; list B ) is a synthetic estrogenic drug of non-steroidal structure of long-acting. It is used in case of insufficiency of ovarian function according to the same indications as other estrogens (see Hormone therapy , Sex hormones ). Dimestrol is administered intramuscularly in a dose of 2 ml of a 0.6% oil solution once a week; 2-3 injections per course. Contraindications and complications are the same as with the use of other estrogens. Product: in 2 ml ampoules of 0.6% oil solution.
Dimestrol (Dimoestrolum) - diethylstilbestrol dimethyl ether or dimethoxy-3,4-diethylstilbene. White crystalline powder with a characteristic odor. Soluble in alcohol, ether, chloroform, vegetable oils. Insoluble in water. Synthetic analogue of folliculin, from which it differs in structure, but has its biological and healing properties. It is less active than synestrol and diethylstilbestrol, but it takes longer to function. Injection of 0.012 drug can act within 1-2 months.
For indications, see Sinestrol, Diethylstilbestrol.
Route of administration. Intramuscularly in oil 0.5% solution.
Doses are individualized depending on the characteristics of the case and the effectiveness of treatment. Usually used by one injection per week in an amount of 12 mg (2 ml or 24 000 IU). During the course of treatment, 2-3 injections are made. The action after the first injection occurs on the 3-6th day.
Contraindications and side effects, see. Synestrol and Diethylstilbestrol.
Form release. Oil solution in ampoules of 2 ml of 0.6% solution (12 mg of the drug in the ampoule).
Saved with caution in the dark place. Refers to list B.
Rp. Dimoestroli 0.6–2.0.
D. S. 2 ml once a week intramuscularly.