Dühring disease (synonym: herpetiform dermatitis, Brock's polymorphic painful dermatitis) is a chronic skin disease characterized by the recurrent appearance of polymorphic rash: blisters, blisters, papular elements. Rash, as a rule, are accompanied by itching or burning, their characteristic feature is the tendency to grouping and symmetrical arrangement. Elements of the rash can be located on the skin of the trunk, limbs, scalp. The palms and soles, as a rule, are free from rashes. In most cases, groups of bubbles or bubbles are located on the swollen, inflamed base, but sometimes bubbles appear on the unchanged skin. The defeat of the mucous membranes is extremely rare. The appearance of rash may be preceded by general malaise. During the period of rash, the temperature can rise to 39 °, itching intensifies , sleep and appetite are disturbed .
The disease can develop in adults and in children.
Eosinophilia in the cystic fluid of patients with herpetiform dermatitis, the absence of so-called acantholytic cells (see Phylosopharya ), which are often marked by increased sensitivity of these people to iodine preparations, are of diagnostic importance. For the purpose of the differential diagnosis of Dühring's disease, the Yadasson's test is applied — an ointment containing 50% potassium iodide applied to healthy skin in the form of a compress. In case of a positive test, after 24 hours, erythema and blisters form at the site of application of the ointment. If the manifestations of the disease are insignificant, 2% potassium iodide solution is administered orally for 1 tablespoon 3 times a day. In case of a positive test, rash of blisters or urticarial elements appear.
The etiology and pathogenesis is not clear. Many authors point to the infectious nature of the disease, others attribute Dühring's disease to trophoneurosis. Of particular importance is attached to pregnancy as a factor contributing to the occurrence of Dühring's disease, as well as endocrine disorders, especially thyroid gland dysfunction .
Treatment . The most effective diaphenylsulfone (DDS), which is prescribed in cycles of 5-10 days with a 3-5-day break (single dose DDS is 0.025 g, daily - 0.075 g); sulfa drugs ; autohemotherapy; corticosteroids. External - aniline dyes and ointments with antibiotics .
Relapse of the disease is possible, as there is no reliable preventive measure for Dühring's disease.