“The fundamentals of the legislation of the USSR and the Union Republics on health care” stipulate that the USSR Ministry of Health is authorized to use medicinal products in medical practice (Article 34). This determines the absolute need for strict observance of the conditions of prescribing and dosages of medicinal products, both practically applied and newly offered, aimed at improving medical care for the population. A special position exists with respect to narcotic and other potent and toxic substances. Their use requires increased caution, the manufacture or sale of these substances, as well as violation of the established rules of production, storage, release, registration, transportation and shipment is a criminal offense (Article 224 of the Criminal Code).
Drugs, even those approved for use in medical practice, under certain conditions can lead to intoxication, causing deterioration of health or death. These conditions include: reactions of the body with simultaneous use of incompatible drugs, exceeding single or total dosages, as well as violation of the relevant instructions on the mode of administration of a particular agent; manifestation of side effects of drugs, especially drug allergies; household poisoning caused by drugs as a result of careless, careless or intentional use.Go
In medical practice, there are cases when drug intoxication occurs due to their pharmaceutical and pharmacotherapeutic incompatibility. Pharmaceutically incompatible substances that enter into physical or chemical reactions, as a result of which the drug becomes unsuitable for use and, consequently, can be harmful to health, may appear in the prescription of the dosage form issued by the doctor. The same can happen even if the prescription of medicines is rationally compiled, but with the simultaneous use of various drugs, their pharmacological incompatibility arises as a natural consequence of the pharmacodynamics of individual drugs being taken into account and at the same time ignoring their combined effect on an organism. In addition to the pharmacological, pharmacotherapeutic incompatibility is known, in which the patient’s organism becomes unfavorable to the interference of a medicinal substance with non-drug factors, for example, food substances.
In the system of formulating medicines, there is a mandatory compliance with the dosages prescribed by the current regulations and instructions. However, in some cases, there are underestimation of contraindications to the use of medicinal substances and their cumulative properties, the clinically unjustified prescription of potent and poisonous drugs, an increase in their single or daily dose, and sometimes self-confidence in their use. Violation of special instructions on the mode of use necessary to obtain a therapeutic effect from the action of drugs (the route and rate of administration, fractional dosages, etc.) may also cause a worsening of the course of the disease and in some cases even death.
For forensic medical examination, the analysis of medical documents ( prescriptions , outpatient or inpatient cards, etc.), explanations of medical workers, examination of the victim using the consultations of relevant specialists, and in the event of death - a forensic medical examination are of special evidentiary value. complex laboratory research methods.Go